Hoekema was born in the Netherlands but immigrated to the United States in 1923. He attended Calvin College (A.B.), the University of Michigan (M.A.), Calvin Theological Seminary (Th.B.) and Princeton Theological Seminary (Th.D., 1953). After pastoring several Christian Reformed churches (1944-56), he became Associate Professor of Bible at Calvin College (1956-58). From 1958 to 1979, when he retired, he was Professor of Systematic Theology at Calvin Theological Seminary in Grand Rapids, Michigan.